Trauma Molecular Pathogenesis and Regeneration Biological Sciences and Molecular Engineering – Postdoctoral (MD or PhD) Trauma Training Program

Location: The University of Chicago · Chicago, Illinois

We are accepting applications for postdoctoral training in trauma related biomedical engineering and biomedical physics. This training experience is funded by an NIH T32 Ruth L. Kirschstein National Research Service Award. Specifically, the training opportunity is focused on molecular pathogenesis of trauma related injury, DNA repair regulation after injury and design of polymers to augment cellular repair. Molecular pathogenesis pertains to the defining the complex intermolecular interactions between unfolded and misfolded proteins in damaged cells as well as the structural alterations of disrupted cell membranes. Furthermore, projects include understanding the chemistry that links molecular alterations to cellular and organismal stress responses. Computational efforts are focused on linking continuum level modeling of scalar potentials to MD simulations. Molecular alterations of trauma-induced membrane and protein alteration critical to the pathogenesis of tissue damage in trauma.

Research in molecular regeneration involves understanding the molecular mechanics of chaperones and the molecular engineering of synthetic molecular chaperones in the form of amphiphilic block copolymers that restore structural integrity of disrupted cell membranes and refold denatured proteins. Directly related research opportunities involves study of oxygen chemistry in metabolically energy-depleted cells, cell death signaling, and nucleic acid repair. Past fellows have been surgical residents or postdoctoral PhD Scientists with appropriate background. Experience in the biophysics and biochemistry of membrane structure, protein folding or chaperonins is desirable. No experience in trauma related injuries necessary.

The training includes formal graduate classes and research using state-of-the-art biophysical facilities and multi- physical and multi-scale computational modeling is an imbedded aspect of the training program has been greatly strengthened by NIH shared instrument award grant that provided a 100 Teraflop Cray supercomputer to address the challenging research questions involved. Trainees in the program will apply the system to investigate molecular mechanics of trauma and injury as well as to elucidate biological function response to certain trauma therapeutic. This unique facility allows whole-body multi-physical multi-scale modeling from continuum to molecular of injury and trauma to derive new insights into the most effective clinical management of major trauma; characterization of transcriptional regulatory networks of pathogenic organisms; and development of image-based biomarkers for tissue metabolic status in response to trauma therapy.

Interested candidates should submit curriculum vitae, letter of interest, and references to:

Applications are accepted at any time.

Raphael C. Lee, MD, ScD (Program Director)
The University of Chicago
Chicago, Illinois 60637

Office Phone: 773-702-6302
r-lee@uchicago.edu
rcleelab.uchicago.edu

 

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